This is not part of the official clinical protocol, but anecdotally reduces the severity of transitional GI symptoms
The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary
10.1001/archpsyc.62.6.593 322
When it comes to the gut, apigenin affects Enterococcus caccae cell wall/membrane synthesis and increases the incidence of protein misfolding Bacteroides galacturonicus growth was also inhibited by apigenin[and] apigenin promoted overall growth and diversity, lowered Firmicutes to Bacteroidetes ratio, and promoted production of short chain fatty acids, including butyrate, which is associated with health (Wang et al., 2017)
But with most of what is available online sold as research grade, quality and safety vary enormously